Expert Answer: AWS Well-Architected Framework provides best practices across six pillars: (1) **Operational Excellence**: IaC (CloudFormation, Terraform), automated deployments (CI/CD), runbook documentation, monitoring/alerting, regular game days, continuous improvement through postmortems; (2) **Security**: defense in depth, IAM least privilege, data encryption, automated compliance scanning, incident response procedures; (3) **Reliability**: multi-AZ deployments, auto-scaling, backup/restore procedures, chaos engineering, change management, SLA monitoring; (4) **Performance Efficiency**: right instance types, caching strategies (ElastiCache, CloudFront), serverless where appropriate, performance testing, architecture reviews; (5) **Cost Optimization**: right-sizing, reserved capacity, storage lifecycle management, cost tagging, regular cost reviews; (6) **Sustainability**: region selection (renewable energy), efficient architectures, utilization optimization, managed services. Application: conduct Well-Architected Reviews quarterly, implement recommendations prioritized by impact, use AWS Well-Architected Tool for automated insights. Similar frameworks: Azure Well-Architected Framework, Google Cloud Architecture Framework.